Kohn-Loncarica, GuillermoFustiñana, AnaDíaz, FrancoJaramillo-Bustamante, Juan C.González-Dambrauskas, SebastiánVásquez-Hoyos, PabloFernández-Sarmiento, JaimeGonzález, GustavoMansur, AlejandroPonce, JavierJabornisky, Roberto2021-08-312021-08-312020Archivos Argententinos de Pediatría 2020;118(6):e514-e526https://doi.org/10.5546/aap.2020.eng.e514http://hdl.handle.net/11447/4542Multisystem inflammatory syndrome temporally related to COVID-19 in children and adolescents is a clinical presentation of SARS-CoV-2 infection. It shares some features with Kawasaki disease, toxic shock, sepsis, macrophage activation syndrome, and myocarditis. Few publications have addressed its initial management, which is similar to that proposed for septic shock. This review analyzes such approach based on the characteristics typical of multisystem inflammatory syndrome related to COVID-19 in accordance with the paradigm of an "institutional practice guideline" and suggests therapeutic approach strategies, including early detection, stabilization, referral, specific treatment, and process analysis.13 p.enCOVID-19SARSCoV-2Multisystem inflammatory syndromePatient care bundlesSepsisArticle