Nigo, MasayukiDiaz, LorenaCarvajal, Lina P.Tran, Truc T.Rios, RafaelPanesso, DianaGaravito, Juan DMiller, WilliamWagner, Audrey2017-08-302017-08-302017Nigo M, Diaz L, Carvajal LP, Tran TT, Rios R, Panesso D, Garavito JD, Miller WR, Wanger A, Weinstock G, Munita JM, Arias CA, Chambers HF. Ceftaroline-Resistant, Daptomycin-Tolerant, and Heterogeneous Vancomycin-Intermediate Methicillin-Resistant Staphylococcus aureus Causing Infective Endocarditis. Antimicrob Agents Chemother. 2017 Feb 23;61(3):e01235-16.http://hdl.handle.net/11447/1620http://dx.doi.org/10.1128/AAC.01235-16We report a case of infective endocarditis (IE) caused by ceftaroline-resistant, daptomycin-tolerant, and heterogeneous vancomycin-intermediate methicillin-resistant S. aureus (MRSA). Resistance to ceftaroline emerged in the absence of drug exposure, and the E447K substitution in the active site of PBP2a previously associated with ceftaroline resistance was identified. Additionally, we present evidence of patient-to-patient transmission of the strain within the same unit. This case illustrates the difficulties in treating MRSA IE in the setting of a multidrug-resistant phenotype.7en-USStaphylococcus aureusceftarolineendocarditisArtículo