Ezquer, FernandoBerríos-Cárcamo, PabloQuezada Diez, Mauricio Alejandro2023-10-252023-10-252023https://repositorio.udd.cl/handle/11447/8021Thesis presented to the School of Medicine Clínica Alemana-Universidad del Desarrollo in order to apply for doctoral degree (PhD) in Sciences and Innovation in MedicineThis thesis presents the results obtained after the simultaneous intranasal and intravenous administration of the antioxidant and anti-inflammatory secretome generated from preconditioned hMSC on the precipitated (naloxone-induced) and spontaneous (oral model) withdrawal syndrome, the reduction in its chronic consumption, and the relapse to voluntary oral consumption (oral model) in rats exposed to continuous doses of opioids. Additionally, the association and role of oxidative stress and neuroinflammation in the different stages of morphine addiction were evaluated.97 p.en090036SMesenchymalSecretomeNeuroinflammationThesishttp://doi.org/10.52611/11447/8021