Gutiérrez M., JoséPinochet F., VíctorIrazoqui G., PaulaBenavides G., GuacoldaAndrade H., ChristianOrellana, MaríaMelo T., Joel2024-06-122024-06-122022Gutiérrez M., José, Pinochet F., Víctor, Irazoqui G., Paula, Benavides G., Guacolda, Andrade H., Christian, Orellana F., María, & Melo T., Joel. (2022). Características clínicas y resultados de pacientes con fibrosis quística con enfermedad pulmonar avanzada. Experiencia en 10 años del Instituto Nacional del Tórax. Revista chilena de enfermedades respiratorias, 38(4), 226-233. https://dx.doi.org/10.4067/S0717-73482022000400226https://hdl.handle.net/11447/9088Advanced cystic fibrosis lung disease (ACFLD) is the leading cause of morbidity and mortality in patients with Cystic Fibrosis (CF). Objective: to describe clinical characteristics of patients with CF with ACFLD and mortality during follow-up. Method: Descriptive, retrospective study of patients with CF and ACFLD: FEV1 ≤ 40%, oxygen dependent, and/or referred to a lung transplant program. Clinical, microbiological, functional, genetic and mortality characteristics were collected. Results: Of 111 controlled patients, 39% met criteria for ACFLD. 52% were men and the mean age was 29,8 yearsold. The average BMI was 19.9 kg/m2, 72% had pancreatic insufficiency and 87% had a genetic study, being the DF508 mutation the most frequent (67%). The average age of diagnosis was 11.2 years (SD ± 13 years), being in 54,5% over the age of 4 years. 75% had chronic Pseudomonas infection. 68% were oxygen dependent and 18% on noninvasive mechanical ventilation. In the last year of follow-up 70% had 2 or more hospitalizations. Of 27 patients who have been referred for transplantation, 7 underwent lung transplantation, 3 died waiting on the transplant list, 9 had contraindications: 4 due to malnutrition and 5 to poor adherence and poor support network. 32% (n = 14) of the ACFLD patients died, 93% due to respiratory causes. Conclusion: 39% of the patients had ACFLD. The average age for CF diagnosis was 11.2 years (SD ± 13 years) Barriers to entering the transplant list are: malnutrition, poor adherence, and lack of a support network. This is a population with a high mortality.esAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)Seres humanosFibrosis quísticaEstudios retrospectivosEstudios de seguimientoComorbilidadesDesnutriciónInfecciones por pseudomonasArticlehttp://dx.doi.org/10.4067/S0717-73482022000400226