Campodónico, PaolaOlivares, BelénTapia, Ricardo A.2021-07-212021-07-212020-07Frontiers in Chemistry, 2020 Jul, vol.8: 583https://doi.org/10.3389/fchem.2020.00583http://hdl.handle.net/11447/4188The mechanism of SNAr reactions between 2-chloro-5-nitropyrimidine with primary and secondary alicyclic amines, respectively, have been studied by kinetic measurements. The kinetic data obtained in aqueous media opens a controversial discussion based on Brönsted-type plots analysis. The first approach based on the kinetic data reveals a non-catalyzed pathway. Then, the subtlety of the mathematical treatment of the kinetic data is discussed over a concerted or stepwise mechanism, respectively.enBrönsted-type plotsMeisenheimer complexSNAr reactionBorder mechanismsReaction mechanismArticle