Cisternas, DanielTaft, TiffanyCarlson, Dustin A.Glasinovic, EstebanMonrroy, HugoRey, PaulaHani, AlbisArdila-Hani, AndrésLeguizamo, Ana MariaBilder, ClaudioDitaranto, AndresVarela, AmandaAgotegaray, JoaquinRemes-Troche, Jose MariaRuiz de León, AntonioPérez de la Serna, JulioMarin, IngridSerra, Jordi2022-05-032022-05-032021Cisternas D, Taft T, Carlson DA, Glasinovic E, Monrroy H, Rey P, Hani A, Ardila-Hani A, Leguizamo AM, Bilder C, Ditaranto A, Varela A, Agotegaray J, Remes-Troche JM, Ruiz de León A, Pérez de la Serna J, Marin I, Serra J. The Spanish version of the esophageal hypervigilance and anxiety score shows strong psychometric properties: Results of a large prospective multicenter study in Spain and Latin America. Neurogastroenterol Motil. 2021 Sep;33(9):e14102. doi: 10.1111/nmo.14102. Epub 2021 Feb 13. PMID: 33580617.https://doi.org/10.1111/nmo.14102http://hdl.handle.net/11447/6052Background: Anxiety is a significant modulator of sensitivity along the GI tract. The recently described Esophageal Hypervigilance and Anxiety Score (EHAS) evaluates esophageal-specific anxiety. The aims of this study were as follows: 1. translate and validate an international Spanish version of EHAS. 2. Evaluate its psychometric properties in a large Hispano-American sample of symptomatic individuals. Methods: A Spanish EHAS version was developed by a Delphi process and reverse translation. Patients referred for high-resolution manometry (HRM) were recruited prospectively from seven Spanish and Latin American centers. Several scores were used: EHAS, Hospital Anxiety and Depression Scale (HADS), Eckardt score (ES), Gastroesophageal Reflux Questionnaire (GERDQ), and the Brief Esophageal Dysphagia Questionnaire (BEDQ). Standardized psychometric analyses were performed. Key results: A total of 443 patients were recruited. Spanish EHAS showed excellent reliability (Cronbach´s alpha = 0.94). Factor analysis confirmed the presence of two factors, corresponding to the visceral anxiety and hypervigilance subscales. Sufficient convergent validity was shown by moderate significant correlations between EHAS and other symptomatic scores. Patients with high EHAS scores had significantly more dysphagia. There was no difference in EHAS scores when compared normal vs abnormal or major manometric diagnosis. Conclusions and inferences: A widely usable Spanish EHAS version has been validated. We confirm its excellent psychometric properties in our patients, confirming the appropriateness of its use in different populations. Our findings support the appropriateness of evaluating esophageal anxiety across the whole manometric diagnosis spectrum.enDysphagia evaluationEsophageal hypervigilance and anxiety score.Esophageal-specific anxietyHigh-resolution manometryPsychometric evaluationReliabilityValidityArticle