Hasbún, María TrinidadZhong, Connie S.Jones, Krystal M.Schmidt, Birgitta A. R.Hussain, Sadaf H.2021-08-172021-08-172020Pediatric Dermatology, 2020, vol. 37(2): 379-380https://dx.doi.org/10.1111/pde.14115http://hdl.handle.net/11447/4346Pemphigus and pemphigus-like reactions can be triggered by a variety of medications including topical therapies, such as imiquimod. While the association between imiquimod and pemphigus-like reactions has been reported in adults, this is the first report of a generalized reaction beyond the site of imiquimod application in a child. The mechanism by which this occurs may be through a unique pathway, separate from the classic antibody-mediated pathway. Our patient had a full recovery without recurrence after cessation of the inciting drug.enDrug reactionImiquimodPemphigus-like reactionArticle