KLEIN, ANDRESOuteiro, Tiago Fleming2023-10-252023-10-252023Klein, A.D., Outeiro, T.F. Glucocerebrosidase mutations disrupt the lysosome and now the mitochondria. Nat Commun 14, 6383 (2023). https://doi.org/10.1038/s41467-023-42107-7https://repositorio.udd.cl/handle/11447/8022β-Glucocerebrosidase (GCase) mutations lead to glucosylceramide build-up in the lysosome, impacting α-synuclein aggregation and autophagy. Recently, Baden and colleagues found GCase in mitochondria, supporting mitochondrial complex I function and energy metabolism. We believe the newly described role of GCase in the mitochondria will inform new Parkinson’s and Gaucher’s disease therapeutics.3 p.enMolecular medicineOrganellesParkinson's diseaseArticlehttps://doi.org/10.1038/s41467-023-42107-7