Sánchez, BrunoCalderon, CristianTapia, Ricardo A.Contreras, RenatoCampodónico, Paola2021-08-272021-08-272018Frontiers in Chemistry. 2018; 6: 509.https://doi.org/10.3389/fchem.2018.00509http://hdl.handle.net/11447/4502Nucleophilic aromatic substitution reactions of 4-chloroquinazoline toward aniline and hydrazine were used as a model system to experimentally show that a substrate bearing heteroatoms on the aromatic ring as substituent is able to establish intramolecular hydrogen bond which may be activated by the reaction media and/or the nature of the nucleophile.enSolvent effectsIonic liquidsCatalysisAnion effectPreferential solvationArticle