Silva Pozo, AndrésVallejos, JoséAlmeida, JuanMartoni, MarianoUribe-San Martin, ReinaldoMiranda, MaríaDíaz, PabloGarcía, DomingaNavia, Víctor2021-11-262021-11-262021Andrés Silva-Pozo, Jose Vallejos, Juan Almeida, Mariano Martoni, Reinaldo Uribe-San Martin, María Miranda, Pablo Diaz, Dominga García, Victor Navía. Impacto de la pandemia de COVID-19 en la gravedad y mortalidad de accidentes cerebrovasculares en el sureste de Santiago, Chile. Revista de accidentes cerebrovasculares y enfermedades cerebrovasculares Volumen 30, Número 11 , noviembre de 2021 , 105953https://doi.org/10.1016/j.jstrokecerebrovasdis.2021.105953http://hdl.handle.net/11447/5127Background and purpose; Chile has been one of the most affected countries by the COVID-19 pandemic, with one of the highest case rates per population. This has affected the epidemiological behaviour of various pathologies. We analyze the impact of the pandemic on the number of admissions due to stroke, its severity and mortality in Santiago, Chile. Methods: a multicenter observational study based on the records of the 3 hospitals of the South East health service in Santiago, Chile. We recorded the number of patients admitted for ischemic stroke between 01 January 2020 and 30 June 2020. We grouped the cases into two periods, pre-pandemic and pandemic, according to the setting of the state of emergency in Chile. Results: 431 patients were admitted with ischemic stroke during the study period. There was a non-significant decrease in weekly admissions (17 vs 15 patients per week). No differences were observed in the proportion of patients with medical treatment (p = 0.810), IVT (p = 0.638), EVT (p = 0.503) or IVT + EVT (p = 0.501). There was a statistically significant increase in the NIHSS on admission (7.23 vs 8.78, p = 0.009) and mortality (5.2% vs 12.4%, p = 0.012). In a multivariate analysis the NIHSS on admission was associated with the increased mortality (RR 1.11, CI 1.04-1.19, p = 0.003). Conclusion: We found an increase in the severity of ischemic stroke on admission and in-hospital mortality during the pandemic period. The main factor to increase in-hospital mortality was the NIHSS on admissionenCOVID-19StrokeMortalityLatin AmericaArticle