brunser, alejandroNuñez; JuanMansilla, EloyCavada, GabrielOlavarría, Verónica V.Munoz Venturelli, PaulaLavados, Pablo2024-04-302024-04-302023Brunser AM, Nuñez JC, Mansilla E, Cavada G, Olavarría V, Muñoz Venturelli P, Lavados PM. Who is in the emergency room matters when we talk about door-to-needle time: a single-center experience. Arq Neuropsiquiatr. 2023 Jul;81(7):624-631. doi: 10.1055/s-0043-1768672https://hdl.handle.net/11447/8698Background: The efficacy of intravenous thrombolysis (IVT) is time-dependent. Objective: To compare the door-to-needle (DTN) time of stroke neurologists (SNs) versus non-stroke neurologists (NSNs) and emergency room physicians (EPs). Additionally, we aimed to determine elements associated with DTN ≤ 20 minutes. Methods: Prospective study of patients with IVT treated at Clínica Alemana between June 2016 and September 2021. Results: A total of 301 patients underwent treatment for IVT. The mean DTN time was 43.3 ± 23.6 minutes. One hundred seventy-three (57.4%) patients were evaluated by SNs, 122 (40.5%) by NSNs, and 6 (2.1%) by EPs. The mean DTN times were 40.8 ± 23, 46 ± 24.7, and 58 ± 22.5 minutes, respectively. Door-to-needle time ≤ 20 minutes occurred more frequently when patients were treated by SNs compared to NSNs and EPs: 15%, 4%, and 0%, respectively (odds ratio [OR]: 4.3, 95% confidence interval [95%CI]: 1.66–11.5, p  = 0.004). In univariate analysis DTN time ≤ 20 minutes was associated with treatment by a SN ( p  = 0.002), coronavirus disease 2019 pandemic period ( p  = 0.21), time to emergency room (ER) ( p  = 0.21), presence of diabetes ( p  = 0.142), hypercholesterolemia ( p  = 0.007), atrial fibrillation ( p  < 0.09), score on the National Institutes of Health Stroke Scale (NIHSS) ( p  = 0.001), lower systolic ( p  = 0.143) and diastolic ( p  = 0.21) blood pressures, the Alberta Stroke Program Early CT Score (ASPECTS; p  = 0.09), vessel occlusion ( p  = 0.05), use of tenecteplase ( p  = 0.18), thrombectomy ( p  = 0.13), and years of experience of the physician ( p  < 0.001). After multivariate analysis, being treated by a SN (OR: 3.95; 95%CI: 1.44–10.8; p  = 0.007), NIHSS (OR: 1.07; 95%CI: 1.02–1.12; p  < 0.002) and lower systolic blood pressure (OR: 0.98; 95%CI: 0.96–0.99; p  < 0.003) remained significant. Conclusion: Treatment by a SN resulted in a higher probability of treating the patient in a DTN time within 20 minutes.enStrokeFibrin Clot Lysis TimeThrombolytic TherapyArticlehttps://doi.org/10.1055/s-0043-1768672