Díaz, FrancoCores, CamilaAtenas, OmarRodríguez, NicolásBustos, RaúlCruces, Pablo2021-12-092021-12-092021Díaz F, Cores C, Atenas O, Rodríguez N, Bustos R, Cruces P. Rationale of Therapeutic Plasma Exchange as Rescue Immunomodulatory Treatment for MIS-C With Multiorgan Failure. Pediatr Infect Dis J. 2021 Jul 1;40(7):e259-e262. doi: 10.1097/INF.0000000000003169.https://doi.org/10.1097/INF.0000000000003169http://hdl.handle.net/11447/5212Multisystem inflammatory syndrome in children (MIS-C) associated with SARS-CoV-2 infection is an infrequent and poorly understood illness. It can present as severe multiorgan failure in children, potentially lethal. Immunomodulation is the empiric treatment because a dysregulated immune response is the primary pathophysiologic mechanism. We present an infant with severe MIS-C, refractory to usual treatment, successfully treated with plasmapheresis.enMIS-CCOVID-19PlasmapheresisArticle