Nardocci, GinoMartín, AldoAbarzúa, SebastiánRodríguez, JorgeSimon, FelipeReyes, EdisonAcuña-Castillo, ClaudioNavarro, CristinaCortés, PaulaFernández, Ricardo2016-05-192016-05-192015Nardocci G, Martin A, Abarzúa S, Rodríguez J, Simon F, Reyes EP, Acuña-Castillo C, Navarro C, Cortes PP, Fernández R. Sepsis progression to multiple organ dysfunction in carotid chemo/baro-denervated rats treated with lipopolysaccharide. J Neuroimmunol. 2015 Jan 15;278:44-52.http://hdl.handle.net/11447/278http://dx.doi.org/10.1016/j.jneuroim.2014.12.002Centro de Fisiología Celular e IntegrativaSepsis progresses to multiple organ dysfunction (MOD) due to the uncontrolled release of inflammatory mediators. Carotid chemo/baro-receptors could play a protective role during sepsis. In anesthetized male rats, we measured cardiorespiratory variables and plasma TNF-α, glucocorticoids, epinephrine, and MOD marker levels 90min after lipopolysaccharide (LPS) administration in control (SHAM surgery) and bilateral carotid chemo/baro-denervated (BCN) rats. BCN prior to LPS blunted the tachypneic response and enhanced tachycardia and hypotension. BCN-LPS rats also showed blunted plasma glucocorticoid responses, boosted epinephrine and TNF-α responses, and earlier MOD onset with a lower survival time compared with SHAM-LPS rats. Consequently, the complete absence of carotid chemo/baro-sensory function modified the neural, endocrine and inflammatory responses to sepsis. Thus, carotid chemo/baro-receptors play a protective role in sepsis.en-USBilateral carotid/sinus neurotomyCarotid bodyEpinephrineGlucocorticoidsMultiple organ dysfunctionSepsisTNF-αTissue damageArtículo