Migeot, JoaquinPina, StefanieHernandez, HernanGonzalez, RaulLegaz, AgustinaFittipaldi, SolResende, Elisa de Paula FrançaDuran, ClaudiaAvila, JoseBehrens, Maria IsabelBruno, MartinCardona, JuanCustodio, NiltonGarcía, AdolfoGodoy, MariaHu, KunLanata, SerggioLawlor, BrianLopera, FranciscoMaito, MarceloMatallana, DianaMiller, BruceMiranda, J JaimeOkada, MairaReyes, PabloSantamaria, HernandoSlachevsky Chonchol, AndreaSosa, AnaTakada, LeonelTorres, JacquelineVanneste, SvenValcour, VictorWen, OliviaYokoyama, JenniferPossin, KatherineIbañez, Agustin2026-07-202026-07-202025Migeot J, Pina-Escudero SD, Hernandez H, Gonzalez-Gomez R, Legaz A, Fittipaldi S, Resende EPF, Duran-Aniotz C, Avila-Funes JA, Behrens MI, Bruno MA, Cardona JF, Custodio N, García AM, Godoy ME, Hu K, Lanata S, Lawlor B, Lopera F, Maito MA, Matallana DL, Miller B, Jaime Miranda J, de Oliveira MO, Reyes P, Santamaria-Garcia H, Slachevsky A, Sosa AL, Takada LT, Torres JM, Vanneste S, Valcour V, Wen O, Yokoyama JS, Possin KL, Ibanez A. Social exposome and brain health outcomes of dementia across Latin America. Nat Commun. 2025 Sep 11;16(1):8196. doi: 10.1038/s41467-025-63277-6https://hdl.handle.net/11447/10864A multidimensional social exposome (MSE)-the combined lifespan measures of education, food insecurity, financial status, access to healthcare, childhood experiences, and more-may shape dementia risk and brain health over the lifespan, particularly in underserved regions like Latin America. However, the MSE effects on brain health and dementia are unknown. We evaluated 2211 individuals (controls, Alzheimer's disease, and frontotemporal lobar degeneration) from a non-representative sample across six Latin American countries. Adverse exposomes associate with poorer cognition in healthy aging. In dementia, more complex exposomes correlate with lower cognitive and functional performance, higher neuropsychiatric symptoms, and brain structural and connectivity alterations in frontal-temporal-limbic and cerebellar regions. Food insecurity, financial resources, subjective socioeconomic status, and access to healthcare emerge as critical predictors. Cumulative exposome measures surpass isolated factors in predicting clinical-cognitive profiles. Multiple sensitivity analyses confirm our results. Findings highlight the need for personalized approaches integrating MSE across the lifespan, emphasizing prevention and interventions targeting social disparities.enAlzheimer Disease / epidemiologyAged80 and overAlzheimer Disease / physiopathologyBrain* / physiopathologyDementia* / physiopathologyExposomeLatin America / epidemiologyArticlehttps://doi.org/10.1038/s41467-025-63277-6