Salgado-Caxito, MaríliaMoreno-Switt, Andrea I.Paes, Antonio CarlosShiva, CarlosMunita, JoséRivas, LinaBenavides, Julio A.2022-01-122022-01-122021Salgado-Caxito M, Moreno-Switt AI, Paes AC, Shiva C, Munita JM, Rivas L, Benavides JA. Higher Prevalence of Extended-Spectrum Cephalosporin-Resistant Enterobacterales in Dogs Attended for Enteric Viruses in Brazil Before and After Treatment with Cephalosporins. Antibiotics (Basel). 2021 Jan 28;10(2):122. doi: 10.3390/antibiotics10020122https://doi.org/10.3390/antibiotics10020122http://hdl.handle.net/11447/5434The extensive use of antibiotics is a leading cause for the emergence and spread of antimicrobial resistance (AMR) among dogs. However, the impact of using antibiotics to treat viral infections on AMR remains unknown. In this study, we compared the prevalence of extended-spectrum cephalosporin-resistant Enterobacterales (ESCR-E) between dogs with a suspected infection of canine parvovirus (CPV) and canine distemper (CDV) before and after treatment with third-generation cephalosporins. We found a higher prevalence of ESCR-E faecal carriage in dogs suspected of CPV (37%) and CDV (15%) compared to dogs with noninfectious pathologies (9%) even prior to the start of their treatment. A 7-day course of ceftriaxone or ceftiofur administrated to CPV and CDV-suspected dogs substantially increased their ESCR-E faecal carriage during treatment (85% for CPV and 57% for CDV), and 4 weeks after the treatment ended (89% for CPV and 60% for CDV) when dogs were back in their households. Most of the observed resistance was carried by ESCR-E. coli carrying blaCTX-M genes. Our results suggest the need to optimize prophylactic antibiotic therapy in dogs treated for a suspected viral infection to prevent ESCR-E emergence and spread in the communityenantimicrobial prophylaxisAntimicrobial resistancecanine distempercanine parvoviruscompanion animalsArticle