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Mild hypothermia attenuates lung edema and plasma interleukin-1 beta in a rat mechanical ventilation-induced lung injury model

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dc.contributor.author Cruces, Pablo
dc.contributor.author Ronco, Ricardo
dc.contributor.author Erranz, Benjamín
dc.contributor.author Conget, Paulette
dc.contributor.author Carvajal, Cristóbal
dc.contributor.author Donoso, Alejandro
dc.contributor.author Díaz, Franco
dc.date.accessioned 2016-12-02T22:43:23Z
dc.date.available 2016-12-02T22:43:23Z
dc.date.issued 2011
dc.identifier.citation Experimental Lung Research, 2011, vol.37, n° 9, p. 549-554 es_CL
dc.identifier.uri http://dx.doi.org/10.3109/01902148.2011.616983 es_CL
dc.identifier.uri http://hdl.handle.net/11447/864
dc.description.abstract Recent data suggest that deep hypothermia has protective effects on experimental induced lung injury. It is not well known if these effects persist with mild hypothermia. The authors hypothesized that mild hypothermia may attenuate lung injury and decrease local and systemic proinflammatory cytokines in a rat model of injurious mechanical ventilation (MV). Twelve Sprague-Dawley male adult rats were anesthetized, intubated, and randomly allocated to normothermia group (37 degrees C) (NT) or mild hypothermia group (34 degrees C) (MH). After 2 hours of deleterious MV (peak inspiratory pressure [PIP] 40 cm H2O, zero end-expiratory pressure [ZEEP], and inspiratory fraction of oxygen [Fio(2)] 100%), arterial blood gases, lung gravimetry, and histological study were obtained. Protein content, interleukin (IL)-1 beta, and tumor necrosis factor (TNF)-alpha were measured in plasma and bronchoalveolar lavage (BAL) fluid. Subjects that underwent MH had a significant lower wet-to-dry lung weight ratio (8.32 +/- 0.28 vs. 10.8 +/- 0.49, P = .01), IL-1 beta plasma concentration (0.6 +/- 0.6 vs. 10.27 +/- 2.80 pg/mL, P = .0048) and Paco(2). There were no differences in terms of Pao(2), histological injury, or BAL protein content. In this model of injurious mechanical ventilation, subjects treated with mild hypothermia had less lung edema and lower plasma IL-1 beta. Some of known beneficial effects of deep hypothermia can be obtained with mild hypothermia. es_CL
dc.language.iso en_US es_CL
dc.subject Therapeutic hypothermia es_CL
dc.subject Ventilator-induced lung injury es_CL
dc.title Mild hypothermia attenuates lung edema and plasma interleukin-1 beta in a rat mechanical ventilation-induced lung injury model es_CL
dc.type Artículo es_CL


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