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Catalytic autoantibodies against myelin basic protein (MBP) isolated from serum of autistic children impair in vitro models of synaptic plasticity in rat hippocampus

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dc.contributor.author González-Gronow, Mario
dc.contributor.author Cuchacovich, Miguel
dc.contributor.author Francos, Rina
dc.contributor.author Cuchacovich, Stephanie
dc.contributor.author Blanco, Ángel
dc.contributor.author Sandoval, Rodrigo
dc.contributor.author Farías Gómez, Cristian
dc.contributor.author Valenzuela, Javier A.
dc.contributor.author Ray, Rupa
dc.contributor.author Pizzo, Salvatore V.
dc.date.accessioned 2016-10-24T21:11:21Z
dc.date.available 2016-10-24T21:11:21Z
dc.date.issued 2015
dc.identifier.citation Journal of Neuroimmunology, 2015, vol287, pp. 1–8
dc.identifier.uri http://hdl.handle.net/11447/791
dc.identifier.uri http://dx.doi.org/10.1016/j.jneuroim.2015.07.006
dc.description.abstract Autoantibodies from autistic spectrum disorder (ASD) patients react with multiple proteins expressed in the brain. One such autoantibody targets myelin basic protein (MBP). ASD patients have autoantibodies to MBP of both the IgG and IgA classes in high titers, but no autoantibodies of the IgM class. IgA autoantibodies act as serine proteinases and degrade MBP in vitro. They also induce a decrease in long-term potentiation in the hippocampi of rats either perfused with or previously inoculated with this IgA. Because this class of autoantibody causes myelin sheath destruction in multiple sclerosis (MS), we hypothesized a similar pathological role for them in ASD.
dc.language.iso en_US
dc.subject Autism
dc.subject Autoimmunity
dc.subject Myelin basic protein
dc.subject Protease antibodies
dc.subject Synaptic plasticity
dc.subject Rat hippocampi
dc.title Catalytic autoantibodies against myelin basic protein (MBP) isolated from serum of autistic children impair in vitro models of synaptic plasticity in rat hippocampus
dc.type Artículo


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