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Cellular immune response induced by surface immunogenic protein with AbISCO-100 adjuvant vaccination decreases group B Streptococcus vaginal colonization.

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dc.contributor.author Soto, Jorge
dc.contributor.author Diaz-Dinamarca, Diego
dc.contributor.author Soto, Daniel
dc.contributor.author Barrientos, Magaly
dc.contributor.author Carrión, Flavio
dc.contributor.author Kalergis, Alexis
dc.contributor.author Vásquez, Abel
dc.date.accessioned 2020-04-08T15:37:38Z
dc.date.available 2020-04-08T15:37:38Z
dc.date.issued 2019
dc.identifier.citation Mol Immunol. 2019 Jul;111:198-204. doi: 10.1016/j.molimm.2019.04.025
dc.identifier.uri http://hdl.handle.net/11447/3218
dc.identifier.uri https://doi.org/10.1016/j.molimm.2019.04.025
dc.description.abstract Group B Streptococcus (GBS) represents one of the most common causes of bacterial infection in neonates; it is also associated with premature childbirth and stillbirth. A vaccine against GBS is needed, but no approved vaccines are yet available. The Surface Immunogenic Protein (SIP) of GBS is conserved in all serotypes and had been reported to be a good vaccine prototype in a mouse model of GBS infection. Also, we have previously shown that both subcutaneous and oral immunization with rSIP can induce an efficient immune response that decreases GBS vaginal colonization in mice. In this study, we show that a vaccine based on a mixture of rSIP and AbISCO-100 adjuvant reduces GBS vaginal colonization in mice and induces antibodies with opsonophagocytic activities. Moreover, the passive transfer of sera and total T-cells from mice immunized with rSIP mixed with AbISCO-100 to unvaccinated mice decreases vaginal GBS colonization in an infected mouse. This is the first report of cellular immunity associated with rSIP-based vaccine testing in a mouse model of GBS infection.
dc.language.iso en
dc.publisher Elsevier Ltd
dc.subject AbISCO-100
dc.subject Group B Streptococcus
dc.subject Cellular immunity
dc.title Cellular immune response induced by surface immunogenic protein with AbISCO-100 adjuvant vaccination decreases group B Streptococcus vaginal colonization.
dc.type Preprint


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