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Proregenerative Microenvironment Triggered by Donor Mesenchymal Stem Cells Preserves Renal Function and Structure in Mice with Severe Diabetes Mellitus.

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dc.contributor.author Ezquer, Fernando
dc.contributor.author Giraud-Billoud, Maximiliano
dc.contributor.author Carpio, Daniel
dc.contributor.author Cabezas, Fabián
dc.contributor.author Conget, Paulette
dc.contributor.author Ezquer, Marcelo
dc.date.accessioned 2016-05-23T19:22:17Z
dc.date.available 2016-05-23T19:22:17Z
dc.date.issued 2015
dc.identifier.citation BioMed Research International, 2015, vol.2015, article ID 164703
dc.identifier.uri http://hdl.handle.net/11447/319
dc.identifier.uri http://dx.doi.org/10.1155/2015/164703
dc.description Centro de Medicina Regenerativa
dc.description.abstract The aim of our work was to evaluate, in an animal model of severe diabetes mellitus, the effect of mesenchymal stem cells (MSCs) administration on diabetic nephropathy (DN) progression. After diabetes induction, one group of mice received the vehicle (DM) and other group received a single dose of MSCs (DM + MSCs). DM + MSCs mice showed a significant improvement in functional parameters of the kidney compared with untreated mice. While DM mice presented marked histopathological changes characteristics of advanced stages of DN (fibrosis, glomerulosclerosis, glomerular basement membrane thickening, capillary occlusion, decreased podocyte density, and effacement of foot processes), DM + MSCs mice showed only slight tubular dilatation. The renoprotection was not associated with an improvement in diabetic condition and very low number of donor cells was found in the kidney of DM + MSCs mice, suggesting that renoprotection could be mediated by paracrine effects. Indeed, DM + MSC mice presented increased renal proliferation index, decreased renal apoptotic index and the restoration of proregenerative factors, and anti-inflammatory cytokines levels. Moreover, macrophage infiltration and oxidative stress damage were also reduced in DM + MSCs mice. Our data demonstrate that MSC administration triggers a proregenerative microenvironment in DN kidney, which allows the preservation of the renal function even if diabetes was uncorrected.
dc.language.iso en_US
dc.publisher Fernando Ezquer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.subject Diabetes Mellitus
dc.subject Mesenchymal stem cell transplantation
dc.subject Mesenchymal stromal cells, physiology
dc.subject Mice
dc.subject Cellular microenvironment
dc.subject Animals
dc.title Proregenerative Microenvironment Triggered by Donor Mesenchymal Stem Cells Preserves Renal Function and Structure in Mice with Severe Diabetes Mellitus.
dc.type Artículo


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