Institutional Repository UDD

Duration of untreated psychosis and acute remission of negative symptoms in a South American first-episode psychosis cohort.

Show simple item record

dc.contributor.author González-Valderrama, Alfonso
dc.contributor.author Castañeda, Carmen Paz
dc.contributor.author Mena, Cristián
dc.contributor.author Undurraga, Juan
dc.contributor.author Mondaca, Pilar
dc.contributor.author Yáñez, Matías
dc.contributor.author Bedregal, Paula
dc.contributor.author Nachar, Rubén
dc.date.accessioned 2016-05-23T18:19:36Z
dc.date.available 2016-05-23T18:19:36Z
dc.date.issued 2015
dc.identifier.citation Early Intervention in Psychiatry, August 2015
dc.identifier.uri http://hdl.handle.net/11447/314
dc.identifier.uri http://dx.doi.org/10.1111/eip.12266
dc.description.abstract AIM: To determine the association between duration of untreated psychosis (DUP) and symptoms remission in a hospitalized first-episode psychosis cohort. METHODS: Inpatients with a first-episode non-affective psychosis were recruited. Subjects were divided into two groups of long and short DUP using a 3-month cut-off point, and this was related to remission at 10 weeks of treatment. Multivariate analyses were performed. RESULTS: Fifty-five inpatients were included. There were no differences in remission rates of positive symptoms. Up to 76.5% of the patients with a short DUP (<3 months) achieved remission of negative symptoms versus 31.6% in the DUP ≥ 3 months group (P = 0.003). After controlling for relevant factors, patients with a shorter DUP were still three times more likely to achieve negative symptoms remission (HR: 3.04, 95% CI 1.2-7.5). CONCLUSIONS: DUP is a prognostic factor that should be considered at an early stage to identify a 'high risk' subgroup of persistent negative symptoms.
dc.language.iso en_US
dc.publisher Wiley Publishing Asia Pty Ltd.
dc.subject Duration of untreated psychosis
dc.subject Early intervention
dc.subject Negative symptom
dc.subject Psychosis
dc.subject Schizophrenia
dc.title Duration of untreated psychosis and acute remission of negative symptoms in a South American first-episode psychosis cohort.
dc.type Artículo


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Browse

My Account