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Sex differences in the risk of rapid cycling and other indicators of adverse illness course in patients with bipolar I and II disorder.

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dc.contributor.author Erol, Almila
dc.contributor.author Winham, Stacey
dc.contributor.author McElroy, Susan
dc.contributor.author Frye, Mark
dc.contributor.author Prieto, Miguel
dc.contributor.author Cuellar-Barboza, Alfredo
dc.contributor.author Fuentes, Manuel
dc.contributor.author Geske, Jennifer
dc.contributor.author Mori, Nicole
dc.contributor.author Biernacka, Joanna
dc.contributor.author Bobo, William
dc.date.accessioned 2016-05-23T18:10:48Z
dc.date.available 2016-05-23T18:10:48Z
dc.date.issued 2015
dc.identifier.citation Bipolar Disorders, September 2015, vol.17, n°6, p.670-676
dc.identifier.uri http://hdl.handle.net/11447/313
dc.identifier.uri http://dx.doi.org/10.1111/bdi.12329
dc.description.abstract OBJECTIVES: To examine the independent effects of sex on the risk of rapid cycling and other indicators of adverse illness course in patients with bipolar I disorder (BP-I) or bipolar II disorder (BP-II). METHODS: We analyzed data from the first 1,225 patients enrolled in the Mayo Clinic Individualized Medicine Biobank for Bipolar Disorder. Demographic and clinical variables were ascertained using standardized questionnaires; height and weight were assessed to determine body mass index (BMI). Rates of rapid cycling, cycle acceleration, and increased severity of mood episodes over time were compared between women and men overall and within subgroups defined by bipolar disorder subtype (BP-I or BP-II). Multiple logistic regression analysis was used to assess the independent effect of sex on the risk of these indicators of adverse illness course. RESULTS: Women had significantly higher rates of rapid cycling than men. Overall rates of rapid cycling were higher in patients with BP-II than BP-I; and sex differences in the rate of rapid cycling were more pronounced in patients with BP-II than BP-I, although the power to detect statistically significant differences was reduced due to the lower sample size of subjects with BP-II. Female sex was a significant predictor of rapid cycling, cycle acceleration, and increased severity of mood episodes over time after adjusting for age, bipolar disorder subtype, BMI, having any comorbid psychiatric disorder, and current antidepressant use. CONCLUSIONS: Female sex was associated with significantly higher risk of rapid cycling, cycle acceleration, and increased severity of mood episodes over time in a sample of 1,225 patients with bipolar disorders.
dc.language.iso en_US
dc.publisher John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
dc.subject Bipolar disorder
dc.subject Cycle acceleration
dc.subject Gender
dc.subject Increased episode severity
dc.subject Rapid cycling
dc.subject Sex
dc.title Sex differences in the risk of rapid cycling and other indicators of adverse illness course in patients with bipolar I and II disorder.
dc.type Artículo


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