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Platelet Count in Patients with Mild Disease at Admission is Associated with Progression to Severe Hantavirus Cardiopulmonary Syndrome

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dc.contributor.author López, René
dc.contributor.author Vial, Cecilia
dc.contributor.author Graf, Jerónimo
dc.contributor.author Calvo, Mario
dc.contributor.author Ferrés, Marcela
dc.contributor.author Mertz, Gregory
dc.contributor.author Cuiza, Analía
dc.contributor.author Agüero, Begonia
dc.contributor.author Aguilera, Dante
dc.contributor.author Araya, Diego
dc.contributor.author Pailamilla, Ignacia
dc.contributor.author Paratori, Flavia
dc.contributor.author Torres-Torres, Víctor
dc.contributor.author Vial, Pablo
dc.contributor.author HantavirusStudy Group in Chile
dc.date.accessioned 2019-08-13T18:52:42Z
dc.date.available 2019-08-13T18:52:42Z
dc.date.issued 2019
dc.identifier.citation López, R.; Vial, C.; Graf, J.; Calvo, M.; Ferrés, M.; Mertz, G.; Cuiza, A.; Agüero, B.; Aguilera, D.; Araya, D.; Pailamilla, I.; Paratori, F.; Torres-Torres, V.; Vial, P.A.; Hantavirus Study Group in Chile. Platelet Count in Patients with Mild Disease at Admission is Associated with Progression to Severe Hantavirus Cardiopulmonary Syndrome. Viruses 2019, 11, 693.
dc.identifier.uri http://hdl.handle.net/11447/2573
dc.identifier.uri doi.org/10.3390/v11080693
dc.description Programa Hantavirus, Instituto de Ciencias e Innovación en Medicina (ICIM)
dc.description.abstract BACKGROUND: Hantavirus cardiopulmonary syndrome (HCPS) has a mortality up to 35-40% and its treatment is mainly supportive. A variable to predict progression from mild to severe disease is unavailable. This study was performed in patients with documented infection by Andes orthohantavirus, and the aim was to find a simple variable to predict progression to moderate/severe HCPS in patients with mild disease at admission. METHODS: We performed a retrospective analysis of 175 patients between 2001 and 2018. Patients were categorized into mild, moderate, and severe disease according to organ failure and advanced support need at hospital admission (e.g., mechanical ventilation, vasopressors). Progression to moderate/severe disease was defined accordingly. Clinical and laboratory variables associated with progression were explored. RESULTS: Forty patients with mild disease were identified; 14 of them progressed to moderate/severe disease. Only platelet count was different between those who progressed versus those that did not (37 (34-58) vs. 83 (64-177) K/mm3, p < 0.001). A ROC curve analysis showed an AUC = 0.889 (0.78-1.0) p < 0.001, with a platelet count greater than 115K /mm3 ruling out progression to moderate/severe disease. CONCLUSIONS: In patients with mild disease at presentation, platelet count could help to define priority of evacuation to tertiary care centers.
dc.language.iso en
dc.subject Hantavirus
dc.subject Hantavirus cardiopulmonary syndrome
dc.subject Hantavirus pulmonary syndrome
dc.subject Thrombocytopenia
dc.subject Cardiopulmonary syndrome
dc.subject Pulmonary syndrome
dc.title Platelet Count in Patients with Mild Disease at Admission is Associated with Progression to Severe Hantavirus Cardiopulmonary Syndrome
dc.type Article


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