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Circulating miR-19b and miR181b are potential biomarkers for diabetic cardiomyopathy

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dc.contributor.author Uribe, Camila
dc.contributor.author León, Luis
dc.contributor.author Fernández, Mauricio
dc.contributor.author Contador, David
dc.contributor.author Calligaris, Sebastián
dc.date.accessioned 2018-01-24T14:21:50Z
dc.date.available 2018-01-24T14:21:50Z
dc.date.issued 2017
dc.identifier.citation Scientific Reports 7, Article number: 13514 (2017)
dc.identifier.uri http://hdl.handle.net/11447/1964
dc.identifier.uri http://dx.doi.org/10.1038/s41598-017-13875-2
dc.description.abstract Diabetic cardiomyopathy is characterized by metabolic changes in the myocardium that promote a slow and silent dysfunction of muscle fibers, leading to myocardium remodelling and heart failure, independently of the presence of coronary artery diseases or hypertension. At present, no imaging methods allow an early diagnosis of this disease. Circulating miRNAs in plasma have been proposed as biomarkers in the prognosis of several cardiac diseases. This study aimed to determine whether circulating miRNAs could be potential biomarkers of diabetic cardiomyopathy. Mice that were fed with a high fat diet for 16 months, showed metabolic syndrome manifestations, cardiac hypertrophy (without hypertension) and a progressive cardiac function decline. At 16 months, when maximal degree of cardiac dysfunction was observed, 15 miRNAs from a miRNA microarray screening in myocardium were selected. Then, selected miRNAs expression in myocardium (at 4 and 16 months) and plasma (at 4, 12 and 16 months) were measured by RT-qPCR. Circulating miR-19b-3p and miR-181b-5p levels were associated with myocardium levels during the development of diabetic cardiomyopathy (in terms of cardiac dysfunction), suggesting that these miRNAs could be suitable biomarkers of this disease in asymptomatic diabetic patients.
dc.format.extent 11
dc.language.iso en_US
dc.publisher Nature Publishing Group
dc.subject Cardiac hypertrophy
dc.subject Diagnostic markers
dc.subject Gene silencing
dc.title Circulating miR-19b and miR181b are potential biomarkers for diabetic cardiomyopathy
dc.type Artículo


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