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Utility of Transbronchial Lung Cryobiopsy in Non-Interstitial Diseases

Show simple item record Sánchez, Olivia Martínez, Dina Fernández‐Bussy, Sebastián López, Berenice Perea, Carolina Rivera, Rosa Luna, Cesar Martínez, José Flores, Luis Santillán, Patricio Reyes, Gustavo 2018-01-22T15:01:44Z 2018-01-22T15:01:44Z 2017
dc.identifier.citation Respiration. 2017;94(3):285-292
dc.description.abstract BACKGROUND: Transbronchial lung cryobiopsy (TLCB), performed with a flexible cryoprobe, is an interventional pulmonology procedure that has proved its diagnostic value for interstitial pulmonary disease. However, it has not been explored extensively as a diagnostic tool for patients with noninterstitial lung pathology, including infectious and malignant diseases. OBJECTIVE: To evaluate the diagnostic yield and safety of an interventional pulmonology approach that integrates TLCB and bronchoalveolar lavage (BAL) for the diagnosis of non-interstitial pulmonary disease. METHODS: TLCB and BAL were performed under general anesthesia through the same bronchoscopic access on 103 adult patients (including immunocompromised HIV+ individuals) with clinical/radiological evidence of non-interstitial lung disease admitted to the Interventional Pulmonology Service between May 2015 and April 2016. Samples obtained were sent to pathology and microbiology laboratories for standard diagnostic analysis. RESULTS: Samples of TLCB allowed the diagnosis of 75.7% of patients, while 39.8% were diagnosed from BAL. The global diagnostic yield from the dual sampling was 92.2%. TLCB allowed the diagnosis of 94.7% of cancer cases and 60.0% of infectious cases, while BAL samples identified 77.5% of infectious cases and 21.2% of malignant lesions. The incidence of complications was 4.9% with full recovery in all cases. CONCLUSIONS: Simultaneous TLCB and BAL constitute a safe and useful diagnostic procedure for non-interstitial pulmonary disease, with a global diagnostic yield of 92.2%. Complementary advantages of samples obtained by each technique result in a robust diagnostic strategy for infectious and malignant disease in adults, including HIV+ individuals.
dc.format.extent 8
dc.language.iso en_US
dc.publisher Karger
dc.subject Cryobiopsy
dc.subject Diagnosis
dc.subject Interventional pulmonology
dc.subject Lung cancer
dc.title Utility of Transbronchial Lung Cryobiopsy in Non-Interstitial Diseases
dc.type Artículo

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