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Associations with health-related quality of life after intracerebral haemorrhage: pooled analysis of INTERACT studies

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dc.contributor.author Delcourt, Candice
dc.contributor.author Zheng, Danni
dc.contributor.author Chen, Xiaoying
dc.contributor.author Hackett, Maree
dc.contributor.author Arima, Hisatomi
dc.contributor.author Hata, Jun
dc.contributor.author Heeley, Emma
dc.contributor.author Al-Shahi Salman, Rustam
dc.contributor.author Woodward, Mark
dc.contributor.author Huang, Yining
dc.contributor.author Robinson, Thompson
dc.contributor.author Lavados, Pablo
dc.contributor.author Lindley, Richard I
dc.contributor.author Stapf, Christian
dc.contributor.author Davies, Leo
dc.contributor.author Chalmers, John
dc.contributor.author Anderson, Craig
dc.contributor.author Sato, Shoichiro
dc.contributor.author INTERACT Investigators
dc.date.accessioned 2017-09-12T12:29:51Z
dc.date.available 2017-09-12T12:29:51Z
dc.date.issued 2017
dc.identifier.citation J Neurol Neurosurg Psychiatry. 2017 Jan;88(1):70-75
dc.identifier.uri http://hdl.handle.net/11447/1673
dc.identifier.uri http://dx.doi.org/10.1136/jnnp-2016-314414
dc.description.abstract BACKGROUND AND PURPOSE: Limited data exist on health-related quality of life (HRQoL) after intracerebral haemorrhage (ICH). We aimed to determine baseline factors associated with HRQoL among participants of the pilot and main phases of the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trials (INTERACT 1 and 2). METHODS: The INTERACT studies were randomised controlled trials of early intensive blood pressure (BP) lowering in patients with ICH (<6 hours) and elevated systolic BP (150-220 mm Hg). HRQoL was determined using the European Quality of Life Scale (EQ-5D) at 90 days, completed by patients or proxy responders. Binary logistic regression analyses were performed to identify factors associated with poor overall HRQoL. RESULTS: 2756 patients were included. Demographic, clinical and radiological factors associated with lower EQ-5D utility score were age, randomisation outside of China, antithrombotic use, high baseline National Institutes of Health Stroke Scale (NIHSS) score, larger ICH, presence of intraventricular extension and use of proxy responders. High (≥14) NIHSS score, larger ICH and proxy responders were associated with low scores in all five dimensions of the EQ-5D. The NIHSS score had a strong association with poor HRQoL (p<0.001). Female gender and antithrombotic use were associated with decreased scores in dimensions of pain/discomfort and usual activity, respectively. CONCLUSIONS: Poor HRQoL was associated with age, comorbidities, proxy source of assessment, clinical severity and ICH characteristics. The strongest association was with initial clinical severity defined by high NIHSS score.
dc.format.extent 6
dc.language.iso en_US
dc.publisher BMJ Publishing Group
dc.subject Cerebral Hemorrhage
dc.subject Quality of life
dc.subject Health
dc.subject Blood Pressure
dc.title Associations with health-related quality of life after intracerebral haemorrhage: pooled analysis of INTERACT studies
dc.type Artículo


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