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Associations with health-related quality of life after intracerebral haemorrhage: pooled analysis of INTERACT studies

Show simple item record Delcourt, Candice Zheng, Danni Chen, Xiaoying Hackett, Maree Arima, Hisatomi Hata, Jun Heeley, Emma Al-Shahi Salman, Rustam Woodward, Mark Huang, Yining Robinson, Thompson Lavados, Pablo Lindley, Richard I Stapf, Christian Davies, Leo Chalmers, John Anderson, Craig Sato, Shoichiro INTERACT Investigators 2017-09-12T12:29:51Z 2017-09-12T12:29:51Z 2017
dc.identifier.citation J Neurol Neurosurg Psychiatry. 2017 Jan;88(1):70-75
dc.description.abstract BACKGROUND AND PURPOSE: Limited data exist on health-related quality of life (HRQoL) after intracerebral haemorrhage (ICH). We aimed to determine baseline factors associated with HRQoL among participants of the pilot and main phases of the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trials (INTERACT 1 and 2). METHODS: The INTERACT studies were randomised controlled trials of early intensive blood pressure (BP) lowering in patients with ICH (<6 hours) and elevated systolic BP (150-220 mm Hg). HRQoL was determined using the European Quality of Life Scale (EQ-5D) at 90 days, completed by patients or proxy responders. Binary logistic regression analyses were performed to identify factors associated with poor overall HRQoL. RESULTS: 2756 patients were included. Demographic, clinical and radiological factors associated with lower EQ-5D utility score were age, randomisation outside of China, antithrombotic use, high baseline National Institutes of Health Stroke Scale (NIHSS) score, larger ICH, presence of intraventricular extension and use of proxy responders. High (≥14) NIHSS score, larger ICH and proxy responders were associated with low scores in all five dimensions of the EQ-5D. The NIHSS score had a strong association with poor HRQoL (p<0.001). Female gender and antithrombotic use were associated with decreased scores in dimensions of pain/discomfort and usual activity, respectively. CONCLUSIONS: Poor HRQoL was associated with age, comorbidities, proxy source of assessment, clinical severity and ICH characteristics. The strongest association was with initial clinical severity defined by high NIHSS score.
dc.format.extent 6
dc.language.iso en_US
dc.publisher BMJ Publishing Group
dc.subject Cerebral Hemorrhage
dc.subject Quality of life
dc.subject Health
dc.subject Blood Pressure
dc.title Associations with health-related quality of life after intracerebral haemorrhage: pooled analysis of INTERACT studies
dc.type Artículo

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