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Specificities of ischemic stroke risk factors in arab-speaking countries

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dc.contributor.author OPTIC Registry and PERFORM Trial Investigators
dc.contributor.author Abboud, Halim
dc.contributor.author Sissani, L
dc.contributor.author Labreuche, J
dc.contributor.author Arauz, Antonio
dc.contributor.author Bousser, M
dc.contributor.author Bryer, A
dc.contributor.author Chamorro, A
dc.contributor.author Fisher, M
dc.contributor.author Ford, I
dc.contributor.author Fox, K
dc.contributor.author Hennerici, M
dc.contributor.author Lavados, Pablo
dc.contributor.author Massaro, A
dc.contributor.author Mattle, Heinrich
dc.contributor.author Munoz Collazos, M
dc.contributor.author Rothwell, P
dc.contributor.author Steg, P
dc.contributor.author Vicaut, E
dc.contributor.author Yamouth, B
dc.contributor.author Amarenco, Pierre
dc.date.accessioned 2017-09-11T16:38:27Z
dc.date.available 2017-09-11T16:38:27Z
dc.date.issued 2017
dc.identifier.citation Cerebrovasc Dis. 2017;43(3-4):169-177
dc.identifier.uri http://hdl.handle.net/11447/1670
dc.identifier.uri http://dx.doi.org/10.1159/000454776
dc.description.abstract Background: Stroke is largely preventable, and therefore, a better understanding of risk factors is an essential step in reducing the population stroke rate and resulting disease burden in Arab countries. Summary: We performed 2 separate analyses in 2 similar populations of patients with noncardioembolic ischemic stroke. This first involved 3,635 patients in the Outcomes in Patients with TIA and Cerebrovascular disease (OPTIC) registry (followed for 2 years), with baseline collection of the usual risk factors and 5 socioeconomic variables (unemployment status, residence in rural area, living in fully serviced accommodation, no health-insurance coverage, and low educational level). The second involved patients in the PERFORM trial (n = 19,100 followed up for 2 years), with baseline collection of the usual risk factors and 1 socioeconomic variable (low educational level). The primary outcome was a composite of nonfatal stroke, nonfatal myocardial infarction, or cardiovascular death. Stroke risk factors were more prevalent in patients in Arab countries. The incidence of major cardiovascular events (MACE; age- and gender-adjusted) was higher in Arab countries (OPTIC, 18.5 vs. 13.3%; PERFORM, 18.4 vs. 9.7%; both p ≤ 0.0001). These results remained significant after adjustment on risk factors and were attenuated in OPTIC after further adjustment on socioeconomic variables (hazard ratio 1.24; 95% CI 0.98-1.55; p = 0.07). Key Messages: Patients with ischemic stroke living in Arab countries had a lower mean socioeconomic status, a much higher prevalence of diabetes mellitus, and a higher rate of MACE compared with patients from non-Arab countries. This finding is partly explained by a higher prevalence of risk factors and also by a high prevalence of poverty and low educational level.
dc.format.extent 9
dc.language.iso en_US
dc.publisher Karger
dc.subject TIA
dc.subject Risk factors
dc.subject socio-economic status
dc.subject stroke
dc.title Specificities of ischemic stroke risk factors in arab-speaking countries
dc.type Artículo


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