Vigabatrin-induced MRI changes associated with extrapyramidal symptoms in a child with infantile spasms
Date
2015
Type:
Artículo
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4
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Journal Title
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Volume Title
Publisher
Sage Publications
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Abstract
Vigabatrin is an antiepileptic drug used for treatment of infantile spasms. We present a female patient with infantile spasms in treatment with vigabatrin who developed ataxic movements. MRI demonstrated a symmetrical pattern of thalamic and globi pallidi diffusion restriction. While these image features have been widely described to be related to the use of vigabatrin, this case highlights the development of movement disorders in association with MRI signal changes. Awareness of the reversible nature of this condition is reassuring for the treating team and avoids unjustified studies.
Description
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Citation
Schonstedt V, Stecher X, Venegas V, Silva C. Vigabatrin-induced MRI changes associated with extrapyramidal symptoms in a child with infantile spasms. Neuroradiol J. 2015 Oct;28(5):515-8
Keywords
Vigabatrin, infantile spasms, ataxic movements, magnetic resonance imaging