Institutional Repository UDD

Exclusion criteria for intravenous thrombolysis in stroke mimics: an observational study

Show simple item record

dc.contributor.author Brunser, Alejandro
dc.contributor.author Illanes, Sergio
dc.contributor.author Lavados, Pablo
dc.contributor.author Muñoz, Paula
dc.contributor.author Carcamo, Daniel
dc.contributor.author Hoppe, Arnold
dc.contributor.author Olavarría, Verónica
dc.contributor.author Delgado, Iris
dc.contributor.author Diaz, Violeta
dc.date.accessioned 2017-04-11T14:05:34Z
dc.date.available 2017-04-11T14:05:34Z
dc.date.issued 2013
dc.identifier.citation J Stroke Cerebrovasc Dis. 2013 Oct;22(7):1140-1145 es_CL
dc.identifier.uri http://doi.org/10.1016/j.jstrokecerebrovasdis.2012.10.019 es_CL
dc.identifier.uri http://hdl.handle.net/11447/1125
dc.description.abstract BACKGROUND: Stroke mimics (SMs) are frequent in emergency departments (EDs), but are treated infrequently with intravenous recombinant tissue plasminogen activator (rt-PA) thrombolysis. We aimed at identifying the factors that lead to the exclusion of SMs from thrombolytic therapy. METHODS: Consecutive patients presenting to the ED between December 2004 and March 2011 with symptoms that suggested acute ischemic stroke were included. RESULTS: Eight hundred forty-two patients were included in this study; 113 (13.4%) were considered SMs; these patients were younger (P = .01), more frequently diabetic (P = .001), arrived later to the ED (P = .03), had lower National Institutes of Health Stroke Scale scores (P < .001), and higher frequencies of negative diffusion-weighted imaging studies (P = .002). The most common causes of cases of SM were toxic metabolic disorders (n = 34 [30.1%]) and seizures (n = 22 [19.5%]). The most frequent cause of consultation was aphasia (n = 43 [37.6%]). SM patients had a total of 152 contraindications for rt-PA, with 34 (30%) patients having >1 contraindication. The most frequent of these were being beyond the therapeutic window for thrombolysis (n = 96) and having deficits not measurable by the National Institutes of Health Stroke Scale or very mild symptoms before the start of rt-PA (n = 37). Twenty-four (21.2%) patients had both contraindications simultaneously. Two patients (1.76%) in the SM group were candidates for rt-PA but did not receive this treatment because they or their family rejected it. Of 729 stroke patients, 87 (11.9%) did receive rt-PA. CONCLUSIONS: SM patients frequently had exclusion criteria for systemic thrombolysis, the most frequent being presenting beyond the established thrombolytic window. es_CL
dc.format.extent 6 es_CL
dc.language.iso en_US es_CL
dc.publisher Elsevier es_CL
dc.subject Stroke es_CL
dc.subject stroke mimics es_CL
dc.subject thrombolysis es_CL
dc.title Exclusion criteria for intravenous thrombolysis in stroke mimics: an observational study es_CL
dc.type Artículo es_CL


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Browse

My Account