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Gadolinium Chloride Rescues Niemann–Pick Type C Liver Damage

Klein, Andrés; Oyarzún, Juan Esteban; Cortez, Cristian; Zanlungo, Silvana (2018)

Niemann–Pick type C (NPC) disease is a rare neurovisceral cholesterol storage disorder that arises from loss of function mutations in the NPC1 or NPC2 genes. Soon after birth, some patients present with an aggressive ...
Ganas de Emprender y Felicidad: Un Estudio Exploratorio a Partir del Global Entrepreneurship Monitor en Chile

Hinojosa Martínez, Sergio; Albornoz Pardo, Carlos (2013)

En este documento se utilizan datos del Global Entrepreneurship Monitor 2012 (GEM) para estimar empíricamente los determinantes de la Intención de Emprender (IE) en Chile, entre los que se incluye la felicidad. Trabajos ...
Gap junction channels and hemichannels in the CNS: regulation by signaling molecules

Orellana, Juan; Martinez, Agustin; Retamal, Mauricio (Elsevier, 2013)

Coordinated interaction among cells is critical to develop the extremely complex and dynamic tasks performed by the central nervous system (CNS). Cell synchronization is in part mediated by connexins and pannexins; two ...
Gap-junctional channel and hemichannel activity of two recently identified connexin 26 mutants associated with deafness

Dalamon, Viviana; Fiori, Mariana; Figueroa, Vania; Oliva, Carolina; Del Río, Rodrigo; González, Wendy; Canan, Jonathan; Elgoyhen, Ana; Altenberg, Guillermo; Retamal, Mauricio (Springer, 2016)

Gap-junction channels (GJCs) are formed by head-to-head association of two hemichannels (HCs, connexin hexamers). HCs and GJCs are permeable to ions and hydrophilic molecules of up to Mr ~1 kDa. Hearing impairment of genetic ...
Gaps, biases, and future directions in research on the impacts of anthropogenic land-use change on aquatic ecosystems: a topic-based bibliometric analysis

Muñoz, Manuel; Fernández, Francisco J.; Ponce Oliva, Roberto; Vásquez-Lavín, Felipe; Gelcich, Stefan (2021)

Anthropogenic land use change (ALUC) satisfies human needs but also impacts aquatic ecosystems. Aquatic ecosystems are intrinsically linked with terrestrial landscapes, an association that is already recognized as a key ...
García García, José Francisco y Verdugo Ramírez, Sergio Ignacio: Activismo Judicial en Chile. ¿Hacia el Gobierno de los Jueces?

Díaz de Valdés, José Manuel (2013)
Gasto de Bolsillo en Salud y Medicamentos en Chile: Análisis Comparativo de los Periodos 1997, 2007, y 2012

Oyarte, Marcela; Espinoza, Manuel; Balmaceda, Carlos; Villegas, Rodrigo; Cabieses, Báltica; Díaz, Janepsy (2018)

Objectives: Out-of-pocket spent (OPS) of health services are considered inefficient and are a consequence of inequalities in financing and access. The main objective of this study was to compare OPS on health and medicine, ...
Gastos hospitalarios en pacientes con fascioliasis en fase aguda, hidatidosis de tratamiento quirúrgico y neurocisticercosis en un hospital general en Chile

Weitzel, Thomas; Fica, Alberto (Sociedad Chilena de Infectología, 2014)

BACKGROUND: Acute fascioliasis (FA), cystic echinococcosis (CE) and neurocysticercosis (NCC) are three endemic parasitic diseases in Chile for whom there is scarce information about the economic impact they represent during ...
Gastroenterology training in Latin America

Cohen, Henry; Sáenz, Roque; De Almeida Troncon, Luiz E.; Lizarzabal, Maribel; Olano, Carolina (2011)

Latin America is characterized by ethnic, geographical, cultural, and economic diversity; therefore, training in gastroenterology in the region must be considered in this context. The continent's medical education is ...
GEM research: achievements and challenges

Alvarez, Claudia; Urbano, David; Amorós, José Ernesto (01/03/2014)

This article analyzes the content and evolution of research based on the Global Entrepreneurship Monitor (GEM) project. We conducted a rigorous search of articles published in journals within the Thomson Reuters’ Social ...
Gender Differences in Transport Perception using Social Media Data

Vásquez-Henríquez, Paula (Universidad del Desarrollo. Facultad de Ingeniería, 2020-10-07)

People often base their mobility decisions on subjective aspects of travel experience, such as time perception, space usage, and safety. It is well recognized that different groups within a population will react differently ...
Gender, age and geographical representation over the past 50 years of schizophrenia research

Alliende, Luz María; Czepielewski, Leticia; Aceituno, David; Castañeda, Carmen Paz; Diaz, Camila; Iruretagoyena, Bárbara; Mena, Carlos; Mena, Cristian; Ramírez, Juan Pablo; Tepper, Ángeles; Vásquez, Javiera; Fonseca, Lais; Machado, Viviane; Hernández, Camilo; Vargas, Cristian; Gómez, Gladys; Kobayashi, Luis; Moncada, Tomás; Evans, Sara; Bressan, Rodrigo; Gama, Clarissa; López, Carlos; De la Fuente, Camilo; González, Alfonso; Undurraga, Juan; Gadelha, Ary; Crossley, Nicolás; ANDES Network (2022)

Previous studies have suggested that subjects participating in schizophrenia research are not representative of the demographics of the global population of people with schizophrenia, particularly in terms of gender and ...
Gene and cell therapy on the acquisition and relapse-like binge drinking in a model of alcoholism: translational options

Israel, Yedy; Quintanilla, María Elena; Ezquer, Fernando; Morales, Paola; Rivera-Meza, Mario; Karahanian, Eduardo; Ezquer, Marcelo; Herrera-Marschitz, Mario (2020)

Studies reviewed show that lentiviral gene therapy directed either at inhibiting the synthesis of brain acetaldehyde generated from ethanol or at degrading brain acetaldehyde fully prevent ethanol intake by rats bred for ...
Genealogía del diseño: un retrato del pensamiento de diseño del siglo XX a la actualidad

Chacón M., Ivette (01/08/2018)

El artículo hace una aproximación en español a la investigación en diseño y sus enfoques, en la que se articulan una serie de eventos centrados en el desarrollo y empleo de los métodos de diseño en la historia contemporánea ...
Generalized inequalities involving fractional operators of the Riemann-Liouville type

Bosch, Paul; Carmenate, Héctor; Rodríguez, José Manuel; Sigarreta, José María (2021)

In this paper, we present a general formulation of the well-known fractional drifts of Riemann-Liouville type. We state the main properties of these integral operators. Besides, we study Ostrowski, Szekely-Clark-Entringer ...
Generation and genetic repair of two human induced pluripotent cell lines from patients with Epidermolysis Bullosa simplex and dilated cardiomyopathy associated with a heterozygous mutation in the translation initiation codon of KLHL24

Ramovs, Veronika; Fuentes, Ignacia; Freund, Christian; Mikkers, Harald; Mummery, Christine L.; Raymond, Karine (2021)

Fibroblasts from two patients carrying a heterozygous mutation in the translation initiation codon (c.2 T > G) of the kelch-like protein 24 (KLHL24) gene were used to generate human induced pluripotent stem cells (hiPSCs), ...
Generative Scholarship Through Prospective Theorizing: Appreciating the Roots and Legacy of Organization Development and Change to Build a Bright Future

Pavez, Ignacio; Godwin, Lindsey; Spreitzer, Gretchen (2021)

How can Organization Development and Change (ODC) research and practice help create healthy, vibrant, and humane organizations and communities? This has been a guiding question for the field of ODC throughout a year-long ...
Generic change indicators in therapeutic processes with different outcomes

Krause, Mariane; Altimir, Carolina; Pérez Ewert, J. Carola; Parra, Guillermo de la (2015)

Objectives: This paper analyzes the relationship between ongoing change and final outcome in therapies carried out in natural settings with 39 clients. Method: Ongoing change was assessed through generic change indicators ...
Genetic and mechanistic diversity in pediatric hemophagocytic lymphohistiocytosis

Chinn, Ivan K.; Eckstein, Olive S.; Peckham-Gregory, Erin C.; Goldberg, Baruch R.; Forbes, Lisa R.; Nicholas, Sarah K.; Mace, Emily M.; Vogel, Tiphanie P.; Abhyankar, Harshal A.; Diaz, Maria I.; Heslop, Helen E.; Krance, Robert A.; Martinez, Caridad A.; Nguyen, Trung C.; Bashir, Dalia A.; Goldman, Jordana R.; Stray-Pedersen, Asbjørg; Pedroza, Luis A.; Poli, Cecilia; Aldave-Becerra, Juan C.; McGhee, Sean A.; Al-Herz, Waleed; Chamdin, Aghiad; Coban-Akdemir, Zeynep H.; Jhangiani, Shalini N.; Muzny, Donna M.; Cao, Tram N.; Hong, Diana N.; Gibbs, Richard A.; Lupski, James R.; Orange, Jordan S.; McClain, Kenneth L.; Allen, Carl E. (2018)

The HLH-2004 criteria are used to diagnose hemophagocytic lymphohistiocytosis (HLH), yet concern exists for their misapplication, resulting in suboptimal treatment of some patients. We sought to define the genomic spectrum ...
Genetic characterization of clinically relevant class 1 integrons carried by multidrug resistant bacteria (MDRB) isolated from the gut microbiota of highly antibiotic treated Salmo salar

Vásquez-Ponce, Felipe; Higuera-Llantén, Sebastián; Parás-Silva, Juan; Gamboa-Acuña, Nicolás; Cortés Salinas, Jimena; Opazo-Capurro, Andrés; Ugalde, Juan A.; Alcalde-Rico, Manuel; Olivares-Pacheco, Jorge (2022)

Objectives The main objective of this study was the genetic characterization of clinically relevant class 1 integrons carried by multidrug resistant bacteria isolated from the intestinal microbiota of aquaculture salmon ...

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