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Extracorporeal membrane oxygenation improves survival in a novel 24-hour pig model of severe acute respiratory distress syndrome

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dc.contributor.author Araos, Joaquín
dc.contributor.author Alegría, Leyla
dc.contributor.author García, Patricio
dc.contributor.author Damiani, Felipe
dc.contributor.author Tapia, Pablo
dc.contributor.author Soto, Dagoberto
dc.contributor.author Salomón, Tatiana
dc.contributor.author Rodríguez, Felipe
dc.contributor.author Amthauer, Macarena
dc.contributor.author Erranz, Benjamín
dc.contributor.author Castro, Gabriel
dc.contributor.author Carreño, Pamela
dc.contributor.author Medina, Tania
dc.contributor.author Retamal, Jaime
dc.contributor.author Cruces, Pablo
dc.contributor.author Bugedo, Guillermo
dc.contributor.author Bruhn, Alejandro
dc.date.accessioned 2017-01-04T15:28:15Z
dc.date.available 2017-01-04T15:28:15Z
dc.date.issued 2016
dc.identifier.citation American Journal of Translational Research, june 2016, vol.8,n°6,p.2826-37 es_CL
dc.identifier.uri http://hdl.handle.net/11447/920
dc.description Centro de Medicina Regenerativa es_CL
dc.description.abstract Extracorporeal membrane oxygenation (ECMO) is increasingly being used to treat severe acute respiratory distress syndrome (ARDS). However, there is limited clinical evidence about how to optimize the technique. Experimental research can provide an alternative to fill the actual knowledge gap. The purpose of the present study was to develop and validate an animal model of acute lung injury (ALI) which resembled severe ARDS, and which could be successfully supported with ECMO. Eighteen pigs were randomly allocated into three groups: sham, ALI, and ALI + ECMO. ALI was induced by a double-hit consisting in repeated saline lavage followed by a 2-hour period of injurious ventilation. All animals were followed up to 24 hours while being ventilated with conventional ventilation (tidal volume 10 ml/kg). The lung injury model resulted in severe hypoxemia, increased airway pressures, pulmonary hypertension, and altered alveolar membrane barrier function, as indicated by an increased protein concentration in bronchoalveolar fluid, and increased wet/dry lung weight ratio. Histologic examination revealed severe diffuse alveolar damage, characteristic of ARDS. Veno-venous ECMO was started at the end of lung injury induction with a flow > 60 ml/kg/min resulting in rapid reversal of hypoxemia and pulmonary hypertension. Mortality was 0, 66.6 and 16.6% in the SHAM, ALI and ALI + ECMO groups, respectively (p < 0.05). This is a novel clinically relevant animal model that can be used to optimize the approach to ECMO and foster translational research in extracorporeal lung support. es_CL
dc.language.iso en_US es_CL
dc.publisher e-Century Pub. Corp es_CL
dc.subject ARDS es_CL
dc.subject ECMO es_CL
dc.subject Mechanical ventilation es_CL
dc.title Extracorporeal membrane oxygenation improves survival in a novel 24-hour pig model of severe acute respiratory distress syndrome es_CL
dc.type Artículo es_CL


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