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Making sense of DSM-5 mania with depressive features

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dc.contributor.author Reinares, María
dc.contributor.author Bonnin, Caterina del Mar
dc.contributor.author Hidalgo-Mazzei, Diego
dc.contributor.author Undurraga, Juan
dc.contributor.author Mur, María
dc.contributor.author Nieto, Evaristo
dc.contributor.author Sáez, Cristina
dc.contributor.author Vieta, Eduard
dc.date.accessioned 2016-05-31T14:22:03Z
dc.date.available 2016-05-31T14:22:03Z
dc.date.issued 2015
dc.identifier.citation Australian & New Zealand Journal of Psychiatry, June 2015, vol. 49, n°. 6, p. 540-549 es_CL
dc.identifier.uri http://dx.doi.org/10.1177/0004867415585583 es_CL
dc.identifier.uri http://hdl.handle.net/11447/346
dc.description.abstract OBJECTIVE: The assessment of the depressive component during mania has become critical for the accurate diagnosis of mixed states, which were defined very narrowly in the past classification systems before Diagnostic and Statistical Manual of Mental Disorders (5th ed.). The aim of this study was to compare socio-demographic, clinical and therapeutic characteristics, as well as clinical and functional outcomes, between manic patients with and without mixed features to validate the relevance of the Diagnostic and Statistical Manual of Mental Disorders (5th ed.) mixed specifier. METHODS: This is a subanalysis of a multicentre naturalistic study MANía Aguda y COnsumo de Recursos (acute mania and health resource consumption [MANACOR]) on the burden of mania in bipolar patients from four hospitals in Catalonia (Spain). The sample consisted of 169 adult patients presenting a manic episode and systematically assessed during a 6-month period. RESULTS: A total of 27% (n = 46/169) of manic patients showed mixed features. Total number of episodes (p = 0.027), particularly depressive and mixed, was greater in manic patients with mixed features, as well as depressive onset (p = 0.018), suicide ideation (p = 0.036), rapid cycling (p = 0.035) and personality disorders (p = 0.071). In contrast, a higher percentage of pure manic subjects were inpatients (p = 0.035), started the illness with mania (p = 0.018) and showed family history of bipolar disorder (p = 0.037), congruent psychotic symptoms (p = 0.001) and cannabis use (p = 0.006). At baseline, pure manic patients received more risperidone (p = 0.028), while mixed patients received more valproate (p = 0.049) and antidepressants (p = 0.005). No differences were found in syndromic recovery at the end of the study. However, depressive change was higher in the mixed group (p = 0.010), while manic change was higher in the pure manic group (p = 0.029). At the end of follow-up, the group with mixed features showed a significant trend towards higher psychosocial dysfunction. CONCLUSION: A total of 27% of manic patients showed mixed features. Groups differed regarding clinical characteristics, course of illness, psychosocial functioning, prescribed treatment and symptom progress. Depressive symptoms in mania should be routinely assessed and considered to guide treatment. es_CL
dc.language.iso spa es_CL
dc.publisher The Royal Australian and New Zealand College of Psychiatrists es_CL
dc.subject Bipolar disorder es_CL
dc.subject Depressive symptoms mania; mixed features es_CL
dc.subject Mania es_CL
dc.title Making sense of DSM-5 mania with depressive features es_CL
dc.type Artículo es_CL


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