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Proregenerative Microenvironment Triggered by Donor Mesenchymal Stem Cells Preserves Renal Function and Structure in Mice with Severe Diabetes Mellitus.

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dc.contributor.author Ezquer, Fernando
dc.contributor.author Giraud-Billoud, Maximiliano
dc.contributor.author Carpio, Daniel
dc.contributor.author Cabezas, Fabián
dc.contributor.author Conget, Paulette
dc.contributor.author Ezquer, Marcelo
dc.date.accessioned 2016-05-23T19:22:17Z
dc.date.available 2016-05-23T19:22:17Z
dc.date.issued 2015
dc.identifier.citation BioMed Research International, 2015, vol.2015, article ID 164703 es_CL
dc.identifier.uri http://dx.doi.org/10.1155/2015/164703 es_CL
dc.identifier.uri http://hdl.handle.net/11447/319
dc.description Centro de Medicina Regenerativa es_CL
dc.description.abstract The aim of our work was to evaluate, in an animal model of severe diabetes mellitus, the effect of mesenchymal stem cells (MSCs) administration on diabetic nephropathy (DN) progression. After diabetes induction, one group of mice received the vehicle (DM) and other group received a single dose of MSCs (DM + MSCs). DM + MSCs mice showed a significant improvement in functional parameters of the kidney compared with untreated mice. While DM mice presented marked histopathological changes characteristics of advanced stages of DN (fibrosis, glomerulosclerosis, glomerular basement membrane thickening, capillary occlusion, decreased podocyte density, and effacement of foot processes), DM + MSCs mice showed only slight tubular dilatation. The renoprotection was not associated with an improvement in diabetic condition and very low number of donor cells was found in the kidney of DM + MSCs mice, suggesting that renoprotection could be mediated by paracrine effects. Indeed, DM + MSC mice presented increased renal proliferation index, decreased renal apoptotic index and the restoration of proregenerative factors, and anti-inflammatory cytokines levels. Moreover, macrophage infiltration and oxidative stress damage were also reduced in DM + MSCs mice. Our data demonstrate that MSC administration triggers a proregenerative microenvironment in DN kidney, which allows the preservation of the renal function even if diabetes was uncorrected. es_CL
dc.language.iso en_US es_CL
dc.publisher Fernando Ezquer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. es_CL
dc.subject Diabetes Mellitus es_CL
dc.subject Mesenchymal stem cell transplantation es_CL
dc.subject Mesenchymal stromal cells, physiology es_CL
dc.subject Mice es_CL
dc.subject Cellular microenvironment es_CL
dc.subject Animals es_CL
dc.title Proregenerative Microenvironment Triggered by Donor Mesenchymal Stem Cells Preserves Renal Function and Structure in Mice with Severe Diabetes Mellitus. es_CL
dc.type Artículo es_CL


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