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Características clínicas y factores pronósticos de la enfermedad meningocóccica: un estudio de serie de casos en Chile durante el brote 2012-2013

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dc.contributor.author Matute, Isabel
dc.contributor.author Olea, Andrea
dc.contributor.author López, Darío
dc.contributor.author Loayza, Sergio
dc.contributor.author Nájera, Manuel
dc.contributor.author González, Claudia
dc.contributor.author Poffald, Lucy
dc.contributor.author Hirmas, Macarena
dc.contributor.author Delgado, Iris
dc.contributor.author Pedroni, Elena
dc.contributor.author Alfaro, Tania
dc.contributor.author Gormaz, Ana María
dc.contributor.author Sanhueza, Gabriel
dc.contributor.author Vial, Pablo
dc.contributor.author Dabanch, Jeannette
dc.contributor.author Gallegos, Doris
dc.contributor.author Aguilera, Ximena
dc.date.accessioned 2016-05-16T18:50:14Z
dc.date.available 2016-05-16T18:50:14Z
dc.date.issued 2015
dc.identifier.citation Revista Chilena de Infetología, Octubre 2015, vol.32, n°5, p.505-516 es_CL
dc.identifier.uri http://dx.doi.org/10.4067/S0716-10182015000600003 es_CL
dc.identifier.uri http://hdl.handle.net/11447/256
dc.description.abstract Introduction: Meningococcal disease (MD) is a major global problem because of its case fatality rate and sequels. Since 2012 cases of serogroup W have increased in Chile, with nonspecific clinical presentation, high case fatality rate and serious consequences. Objective: To characterize the evolution and outcome of MD cases between January 2012 and March 2013 in Chile. Material and Methods: Case series considering149 MD cases of 7 regions. A questionnaire was applied and clinical records were reviewed, including individual, agent, clinical course and healthcare process variables. The analysis allowed to obtain estimates of the OR as likelihoodof dying. Results: 51.5% was meningococcemia, the case fatality rate reached 27%, prevailing serogroup W (46.6%). Factors that increased the probability of dying: > age, belonging to indigenous people, having lived a stressful event, having diarrhea, impaired consciousness, cardiovascular symptoms, low oxygen saturation and low Glasgow coma scale score. Discussion: The case fatality rate exceeded normal levels and was higher in serogroup W. Increasing in this serogroup, associated to the increased presence of nonspecific symptoms or rapid progression to septicemia, hit a health system accustomed to more classic meningococcal disease presentation, which could partly explain the observed increased fatality rate. es_CL
dc.language.iso spa es_CL
dc.publisher Sociedad Chilena de Infectología es_CL
dc.subject Meningococcal disease es_CL
dc.subject Serogroup es_CL
dc.subject Case fatality rate es_CL
dc.title Características clínicas y factores pronósticos de la enfermedad meningocóccica: un estudio de serie de casos en Chile durante el brote 2012-2013 es_CL
dc.title.alternative Clinical features and prognostic factors of meningococcal disease: a case series study in Chile during the 2012-2013 outbreak es_CL
dc.type Artículo es_CL


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