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Theta and Alpha Oscillation Impairments in Autistic Spectrum Disorder Reflect Working Memory Deficit

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dc.contributor.author Larrain-Valenzuela, Josefina
dc.contributor.author Zamorano, Francisco
dc.contributor.author Soto-Icaza, Patricia
dc.contributor.author Carrasco, Ximena
dc.contributor.author Herrera, Claudia
dc.contributor.author Daiber, Francisca
dc.contributor.author Aboitiz, Francisco
dc.contributor.author Billeke, Pablo
dc.date.accessioned 2018-02-22T21:43:22Z
dc.date.available 2018-02-22T21:43:22Z
dc.date.issued 2017
dc.identifier.citation Scientific Reports Vol. 7, Article number : 14328(2017) es_CL
dc.identifier.uri http://dx.doi.org/10.1038/s41598-017-14744-8 es_CL
dc.identifier.uri http://hdl.handle.net/11447/1996
dc.description.abstract A dysfunction in the excitatory–inhibitory (E/I) coordination in neuronal assembly has been proposed as a possible neurobiological mechanism of Autistic Spectrum Disorder (ASD). However, the potential impact of this mechanism in cognitive performance is not fully explored. Since the main consequence of E/I dysfunction is an impairment in oscillatory activity and its underlying cognitive computations, we assessed the electroencephalographic activity of ASD and typically developing (TD) subjects during a working-memory task. We found that ASD subjects committed more errors than TD subjects. Moreover, TD subjects demonstrated a parametric modulation in the power of alpha and theta band while ASD subjects did not demonstrate significant modulations. The preceding leads to significant differences between the groups in both the alpha power placed on the occipital cortex and the theta power placed on the left premotor and the right prefrontal cortex. The impaired theta modulation correlated with autistic symptoms. The results indicated that ASD may present an alteration in the recruitment of the oscillatory activity during working-memory, and this alteration could be related to the physiopathology of the disorder. es_CL
dc.language.iso en_US es_CL
dc.subject Working memory es_CL
dc.subject Autism spectrum disorders es_CL
dc.title Theta and Alpha Oscillation Impairments in Autistic Spectrum Disorder Reflect Working Memory Deficit es_CL
dc.type Artículo es_CL


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