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Corneal Cross-Linking in Pediatric Patients With Progressive Keratoconus

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dc.contributor.author Wise, Stephanie
dc.contributor.author Diaz, Christian
dc.contributor.author Termote, Karolien
dc.contributor.author Dubord, Paul
dc.contributor.author McCarthy, Martin
dc.contributor.author Yeung, Sonia
dc.date.accessioned 2018-02-01T14:10:49Z
dc.date.available 2018-02-01T14:10:49Z
dc.date.issued 2016
dc.identifier.citation Cornea: November 2016 - Volume 35 - Issue 11 - p 1441–1443 es_CL
dc.identifier.uri http://dx.doi.org/10.1097/ICO.0000000000000923 es_CL
dc.identifier.uri http://hdl.handle.net/11447/1986
dc.description.abstract Purpose: To evaluate corneal cross-linking (CXL) in the treatment of keratoconus in pediatric patients. Specifically, this study investigates the impact of CXL on uncorrected distance visual acuity (UDVA), best-corrected distance visual acuity (BDVA), manifest refraction, keratometry (K) measurements, and higher order aberrations. Methods: This is a retrospective, observational case series of patients 18 years old or younger with progressive keratoconus who underwent CXL from January 2009 to August 2013. Preoperative and 1-year postoperative data including BDVA, manifest refraction, mean K readings, and corneal aberration measurements were extracted from clinical charts and topographical imaging. Visual acuity was converted to logarithm of the minimum angle of resolution (logMAR) scale, and mean refractive spherical equivalent (MRSE) was calculated from manifest refraction. Results: The group consisted of 39 eyes from 28 patients, including 21 males and 7 females (mean age = 16.3 years, range: 11–18, standard deviation [SD] = 1.81). UDVA did not change significantly (preoperative UDVA = 1.20 logMAR, SD = 0.57, and postoperative UDVA = 0.90 logMAR, SD = 0.67, P = 0.19). BDVA did not change significantly (preoperative BDVA = 0.34 logMAR, SD = 0.27, and postoperative BDVA = 0.34 logMAR, SD = 0.23, P = 0.50). There was no significant change in mean K (preoperative K = 48.49, SD = 5.44, and postoperative K = 48.25, SD = 4.74, P = 0.34). Mean MRSE did not change significantly (preoperative MRSE = −3.29 D, SD = 4.04, and postoperative MRSE = −3.53 D, SD = 4.07, P = 0.31). Corneal aberration measurements were available for 10 eyes, and stability of measurements was demonstrated. There were no complications noted. Conclusions: This study suggests that CXL is a safe and effective procedure that halts the progression of keratoconus in pediatric patients at 1-year follow-up. To validate these findings, longer follow-up is required. es_CL
dc.format.extent 3 es_CL
dc.language.iso en_US es_CL
dc.publisher Lippincott Williams & Wilkins es_CL
dc.subject cross-linking es_CL
dc.subject keratoconus es_CL
dc.subject pediatrics es_CL
dc.title Corneal Cross-Linking in Pediatric Patients With Progressive Keratoconus es_CL
dc.type Artículo es_CL


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