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Intracerebral hemorrhage location and outcome among INTERACT2 participants.

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dc.contributor.author INTERACT2 Investigators
dc.contributor.author Delcourt, Candice
dc.contributor.author Sato, Shoichiro
dc.contributor.author Zhang, Shihong
dc.contributor.author Sandset, Else Charlotte
dc.contributor.author Zheng, Danni
dc.contributor.author Chen, Xiaoying
dc.contributor.author Hackett, Maree L.
dc.contributor.author Arima, Hisatomi
dc.contributor.author Hata, Jun
dc.contributor.author Heeley, Emma
dc.contributor.author Al-Shahi Salman, Rustam
dc.contributor.author Robinson, Thompson
dc.contributor.author Davies, Leo
dc.contributor.author Lavados, Pablo
dc.contributor.author Lindley, Richard I.
dc.contributor.author Stapf, Christian
dc.contributor.author Chalmers, John
dc.contributor.author Anderson, Craig
dc.date.accessioned 2017-09-12T12:09:27Z
dc.date.available 2017-09-12T12:09:27Z
dc.date.issued 2017
dc.identifier.citation Neurology. 2017 Apr 11; 88(15): 1408–1414 es_CL
dc.identifier.uri http://dx.doi.org/10.1212/WNL.0000000000003771 es_CL
dc.identifier.uri http://hdl.handle.net/11447/1671
dc.description.abstract OBJECTIVE: To clarify associations between intracerebral hemorrhage (ICH) location and clinical outcomes among participants of the main phase Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2). METHODS: Associations between ICH sites and poor outcomes (death [6] or major disability [3-5] of modified Rankin Scale) and European Quality of Life Scale (EQ-5D) utility scores at 90 days were assessed in logistic regression models. RESULTS: Of 2,066 patients included in the analyses, associations were identified between ICH sites and poor outcomes: involvement of posterior limb of internal capsule increased risks of death or major disability (odds ratio [OR] 2.10) and disability (OR 1.81); thalamic involvement increased risks of death or major disability (OR 2.24) and death (OR 1.97). Involvement of the posterior limb of the internal capsule, thalamus, and infratentorial sites were each associated with poor EQ-5D utility score (≤0.7 [median]; OR 1.87, 2.14, and 2.81, respectively). Posterior limb of internal capsule involvement was strongly associated with low scores across all health-related quality of life domains. ICH encompassing the thalamus and posterior limb of internal capsule were associated with death or major disability, major disability, and poor EQ-5D utility score (OR 1.72, 2.26, and 1.71, respectively). CONCLUSION: Poor clinical outcomes are related to ICH affecting the posterior limb of internal capsule, thalamus, and infratentorial sites. The highest association with death or major disability and poor EQ-5D utility score was seen in ICH encompassing the thalamus and posterior limb of internal capsule. CLINICALTRIALSGOV REGISTRATION: NCT00716079. es_CL
dc.format.extent 7 es_CL
dc.language.iso en_US es_CL
dc.publisher American Academy of Neurology es_CL
dc.subject Antihypertensive Agents es_CL
dc.subject Blood Pressure es_CL
dc.subject Cerebral Hemorrhage es_CL
dc.subject Disabled Persons es_CL
dc.subject Outcome Assessment (Health Care) es_CL
dc.title Intracerebral hemorrhage location and outcome among INTERACT2 participants. es_CL
dc.type Artículo es_CL


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