Para entender la acción del cortisol en inflamación aguda: una mirada desde la glándula suprarrenal hasta la célula blanco

Date

2017

Type:

Artículo

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10

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ORCID:

Journal Title

Journal ISSN

Volume Title

Publisher

Sociedad Medica de Santiago

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Abstract

Glucocorticoids (cortisol in humans) are essential for numerous biological functions. Among critically ill patients, therapy with cortisol has gained strength in recent years, but clinical results have been mixed. A series of events, that may explain the diversity of clinical responses, occur from the synthesis of cortisol in the adrenal gland to the activation of the cortisol receptor by the hormone when it enters the nucleus of the target cell. Some of these events are revised; a proposition for identifying critically ill patients who may benefit with this therapy is suggested.

Description

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Citation

Rev Med Chile 2017; 145: 230-239

Keywords

Adrenal Insufficiency, Critical Care, Hydrocortisone, Receptor, Glucocorticoid

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