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The histaminergic tuberomamillary nucleus is involved in appetite for sex, water and amphetamine

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dc.contributor.author Contreras, Marco
dc.contributor.author Riveros, Maria
dc.contributor.author Quispe, Maricel
dc.contributor.author Sanchez, Cristian
dc.contributor.author Perdomo, Guayec
dc.contributor.author Torrealba, Fernando
dc.contributor.author Valdes, Jose
dc.date.accessioned 2017-05-10T13:15:19Z
dc.date.available 2017-05-10T13:15:19Z
dc.date.issued 2016
dc.identifier.citation PLoS One. 2016; 11(2): e0148484 es_CL
dc.identifier.uri http://dx.doi.org/10.1371/journal.pone.0148484 es_CL
dc.identifier.uri http://hdl.handle.net/11447/1222
dc.description.abstract The histaminergic system is one component of the ascending arousal system which is involved in wakefulness, neuroendocrine control, cognition, psychiatric disorders and motivation. During the appetitive phase of motivated behaviors the arousal state rises to an optimal level, thus giving proper intensity to the behavior. Previous studies have demonstrated that the histaminergic neurons show an earlier activation during the appetitive phase of feeding, compared to other ascending arousal system nuclei, paralleled with a high increase in arousal state. Lesions restricted to the histaminergic neurons in rats reduced their motivation to get food even after 24h of food deprivation, compared with intact or sham lesioned rats. Taken together, these findings indicate that the histaminergic system is important for appetitive behavior related to feeding. However, its role in other goal-directed behaviors remains unexplored. In the present work, male rats rendered motivated to obtain water, sex, or amphetamine showed an increase in Fos-ir of histaminergic neurons in appetitive behaviors directed to get those reinforcers. However, during appetitive tests to obtain sex, or drug in amphetamine-conditioned rats, Fos expression increased in most other ascending arousal system nuclei, including the orexin neurons in the lateral hypothalamus, dorsal raphe, locus coeruleus and laterodorsal tegmental neurons, but not in the ventral tegmental area, which showed no Fos-ir increase in any of the 3 conditions. Importantly, all these appetitive behaviors were drastically reduced after histaminergic cell-specific lesion, suggesting a critical contribution of histamine on the intensity component of several appetitive behaviors. es_CL
dc.format.extent 13 es_CL
dc.language.iso en_US es_CL
dc.publisher PLoS es_CL
dc.subject histaminergic system es_CL
dc.subject Rats es_CL
dc.subject appetitive phase es_CL
dc.title The histaminergic tuberomamillary nucleus is involved in appetite for sex, water and amphetamine es_CL
dc.type Artículo es_CL


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