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Relevance of the carotid body chemoreflex in the progression of heart failure

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dc.contributor.author Andrade, David
dc.contributor.author Lucero, Claudia
dc.contributor.author Toledo, Camilo
dc.contributor.author Madrid, Carlos
dc.contributor.author Marcus, Noah
dc.contributor.author Schultz, Harold
dc.contributor.author Del Río, Rodrigo
dc.date.accessioned 2017-05-19T03:49:55Z
dc.date.available 2017-05-19T03:49:55Z
dc.date.issued 2015
dc.identifier.citation Biomed Res Int. 2015;2015:467597 es_CL
dc.identifier.uri http://dx.doi.org/10.1155/2015/467597 es_CL
dc.identifier.uri http://hdl.handle.net/11447/1175
dc.description Centro de Fisiología Celular e Integrativa es_CL
dc.description.abstract Chronic heart failure (CHF) is a global health problem affecting millions of people. Autonomic dysfunction and disordered breathing patterns are commonly observed in patients with CHF, and both are strongly related to poor prognosis and high mortality risk. Tonic activation of carotid body (CB) chemoreceptors contributes to sympathoexcitation and disordered breathing patterns in experimental models of CHF. Recent studies show that ablation of the CB chemoreceptors improves autonomic function and breathing control in CHF and improves survival. These exciting findings indicate that alterations in CB function are critical to the progression of CHF. Therefore, better understanding of the physiology of the CB chemoreflex in CHF could lead to improvements in current treatments and clinical management of patients with CHF characterized by high chemosensitivity. Accordingly, the main focus of this brief review is to summarize current knowledge of CB chemoreflex function in different experimental models of CHF and to comment on their potential translation to treatment of human CHF. es_CL
dc.format.extent 7 es_CL
dc.language.iso en_US es_CL
dc.publisher Hindawi Publishing Corp. es_CL
dc.subject Carotid Body/physiopathology es_CL
dc.subject Heart Failure/physiopathology es_CL
dc.subject Respiration es_CL
dc.subject Sympathetic Nervous System/physiopathology es_CL
dc.title Relevance of the carotid body chemoreflex in the progression of heart failure es_CL
dc.type Artículo es_CL


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