Institutional Repository UDD

Life-threatening complications following orthognathic surgery in a patient with undiagnosed hereditary angioedema

Show simple item record Cifuentes, Julio Palisson, Francis Valladares, Salvador Jerez, Daniel 2017-04-17T13:37:53Z 2017-04-17T13:37:53Z 2013
dc.identifier.citation J Oral Maxillofac Surg. 2013 Apr;71(4):e185-188 es_CL
dc.identifier.uri es_CL
dc.description.abstract As described in the literature, hereditary angioedema (HAE) is an autosomal dominant disease that presents with recurrent events of angioedema caused by a) deficiency or b) functional alteration of the plasma protein C1 inhibitor (C1-inh); this enzyme is involved in the regulation of the complement, kallikrein-kinin, fibrinolytic, and coagulation systems. HAE is characterized by episodes of edema in the larynx, facial structures and tissues, gastrointestinal tract, or extremities. Laryngeal edema has been reported to occur predominantly after oral surgery. We describe the case of an 18-year-old Asiatic male, reporting an unremarkable medical history, who experienced complications following orthognathic surgery. Thirty hours post-op, the patient developed severe facial, pharyngeal, and glottic edema that compromised the airway, and an emergency tracheal intubation was performed. He was tested for C1-inh plasma levels, showing a sub-normal concentration and indicating a diagnosis of HAE. The patient received fresh-frozen plasma and improved throughout the day as his condition stabilized. Several cases of HAE following oral surgery have been reported, but, to the authors' knowledge, this is the first case reported following orthognathic surgery. This patient's treatment will be described, and a literature review of the disease and management methods will be provided. es_CL
dc.format.extent 4 es_CL
dc.language.iso en_US es_CL
dc.publisher Elsevier es_CL
dc.subject Airway Obstruction/etiology es_CL
dc.subject Hereditary Angioedema Types I and II/complications es_CL
dc.subject Osteotomy, Le Fort es_CL
dc.subject Osteotomy, Sagittal Split Ramus es_CL
dc.subject Postoperative Complications es_CL
dc.title Life-threatening complications following orthognathic surgery in a patient with undiagnosed hereditary angioedema es_CL
dc.type Artículo es_CL

Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


My Account