Institutional Repository UDD

Safety of the intravenous administration of neurotensin-polyplex nanoparticles in BALB/c mice

Show simple item record Hernandez, Maria Rembao, Jesus Hernandez-Baltazar, Daniel Castillo-Rodriguez, Rosa Tellez-Lopez, Victor Flores-Martinez, Yazmin 2017-03-13T19:54:17Z 2017-03-13T19:54:17Z 2014
dc.identifier.citation Nanomedicine. 2014 May;10(4):745-54 es_CL
dc.identifier.uri es_CL
dc.description Centro de Medicina Regenerativa es_CL
dc.description.abstract Neurotensin (NTS)-polyplex is a gene nanocarrier that has potential nanomedicine-based applications for the treatment of Parkinson's disease and cancers of cells expressing NTS receptor type 1. We assessed the acute inflammatory response to NTS-polyplex carrying a reporter gene in BALB/c mice. The intravenous injection of NTS-polyplex caused the specific expression of the reporter gene in gastrointestinal cells. Six hours after an intravenous injection of propidium iodide labeled-NTS-polyplex, fluorescent spots were located in the cells of the organs with a mononuclear phagocyte system, suggesting NTS-polyplex clearance. In contrast to lipopolysaccharide and carbon tetrachloride, NTS-polyplex did not increase the serum levels of tumor necrosis factor alpha, interleukin (IL)-1β, IL-6, bilirubin, aspartate transaminase, and alanine transaminase. NTS-polyplex increased the levels of serum amyloid A and alkaline phosphatase, but these levels normalized after 24 h. Compared to carrageenan, the local injection of NTS-polyplex did not produce inflammation. Our results support the safety of NTS-polyplex. es_CL
dc.format.extent 10 es_CL
dc.language.iso en_US es_CL
dc.publisher Future Medicine es_CL
dc.subject Biosafety es_CL
dc.subject Cytotoxicity es_CL
dc.subject Nanomaterials es_CL
dc.subject Pro-inflammatory cytokines es_CL
dc.title Safety of the intravenous administration of neurotensin-polyplex nanoparticles in BALB/c mice es_CL
dc.type Artículo es_CL

Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


My Account