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Neural reflex regulation of systemic inflammation: potential new targets for sepsis therapy

Show simple item record Fernandez, Ricardo Nardocci, Gino Navarro, Cristina Reyes, Edison Acuña-Castillo, Claudio Cortes, Paula 2017-03-07T15:33:30Z 2017-03-07T15:33:30Z 2014
dc.identifier.citation Front Physiol. 2014; 5: 489 es_CL
dc.identifier.uri es_CL
dc.description Centro de Fisiología Celular e Integrativa es_CL
dc.description.abstract Sepsis progresses to multiple organ dysfunction due to the uncontrolled release of inflammatory mediators, and a growing body of evidence shows that neural signals play a significant role in modulating the immune response. Thus, similar toall other physiological systems, the immune system is both connected to and regulated by the central nervous system. The efferent arc consists of the activation of the hypothalamic–pituitary–adrenal axis, sympathetic activation, the cholinergic anti-inflammatory reflex, and the local release of physiological neuromodulators. Immunosensory activity is centered on the production of pro-inflammatory cytokines, signals that are conveyed to the brain through different pathways. The activation of peripheral sensory nerves, i.e., vagal paraganglia by the vagus nerve, and carotid body (CB) chemoreceptors by the carotid/sinus nerve are broadly discussed here. Despite cytokine receptor expression in vagal afferent fibers, pro-inflammatory cytokines have no significant effect on vagus nerve activity. Thus, the CB may be the source of immunosensory inputs and incoming neural signals and, in fact, sense inflammatory mediators, playing a protective role during sepsis. Considering that CB stimulation increases sympathetic activity and adrenal glucocorticoids release, the electrical stimulation of arterial chemoreceptors may be suitable therapeutic approach for regulating systemic inflammation. es_CL
dc.format.extent 9 es_CL
dc.language.iso en_US es_CL
dc.publisher Frontiers Research Foundation es_CL
dc.subject systemic inflammation es_CL
dc.subject sepsis es_CL
dc.subject reflex control of inflammation es_CL
dc.subject carotid body es_CL
dc.subject vagus nerve es_CL
dc.title Neural reflex regulation of systemic inflammation: potential new targets for sepsis therapy es_CL
dc.type Artículo es_CL

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